Bullet Blender是一款新颖、快速、高通量、高稳定性的组织细胞破碎仪。使用专利的试管击打技术，转头以每分钟几千次的频率击打试管，使样品在试管内产生剧烈的振动，从而达到有效的混合。在样品中加入不同规格的高耐磨性研磨珠，可对细胞或组织样品进行彻底的破碎和均质，提取样品中的核酸、蛋白、亚细胞结构或其它有机成分。避免了手工研磨、机械匀浆、超声波处理等传统方法费时、费力、效率低、效果差、重现性差和易交叉污染等缺点。同时由于其创新的设计，也成为了世界上性价比最高的大通量组织细胞破碎仪。
Bullet Blender的特点：
● 高通量样品处理能力，单次处理时间一般不超过3分钟，大大提高了实验室的工作效率；
● 不同型号分别可容纳24个1.5/2mL离心管、12个5ml离心管（Blue 5型）或8个50mL离心管（50-DX型）；
● 不需要特殊样品管，推荐使用Eppendorf的1.5mL（可液氮预冻）、2mL微量离心管和5mL离心管，BD falcon的50mL离心管，大大降低使用成本；
● 非接触式样品处理方式，整个过程中样品都保持密封，无交叉污染发生；
● 24伏直流马达，产热量小，除转头外，无其它活动部件，使用寿命更长；
● 具有强制风冷功能，降低仪器和样品的热累积，最大限度的避免核酸、蛋白质等生物活性物质因高温而降解；
● 处理时间1到5分钟和3到15分钟(50ml型)可调，或直接按启动键可进行短时间处理；
● 转头速度从低速漩涡混合到高速剧烈振动10档可选；
● 紧凑的设计，20cm (直径)×19cm(高)，只需电源即可在实验室任何一个地方使用；
● 可放置于4℃到60℃的环境中运行；
● 提供各种尺寸和材质的研磨珠，满足处理不同样品的需要；
● 对于用户的特殊样品，提供具有针对性的实验方案；
针对不同的用户，Bullet Blender具有多个型号供选择，分别是：
● Bullet Blender（BBX24）：适用1.5/2.0ml微量离心管，可同时处理24个样品，不带风冷功能；
● Bullet Blender Blue（BBX24B）：适用1.5/2.0ml微量离心管，可同时处理24个样品，带风冷功能；
● Bullet Blender（BBX24W）：适用1.5ml旋盖离心管（带密封圈），可同时处理24个样品，带风冷功能，适合处理生物危险类样品；
● Bullet Blender Blue 5（BBX5MB）：适用5.0ml离心管，可同时处理12个样品，适用于中等强度的样品，带风冷功能；
● Bullet Blender 50-DX（BB50-DX）：适用50ml离心管，可同时处理8个样品，适用于较易破碎的样品，带风冷功能；
● Field Blender（FBBX）：适用1.5/2.0ml微量离心管，内置电池，方便在野外对样品进行处理，电池驱动，一次可处理6个样品；室内通电使用，和普通型号性能一样；
● BioBox Blender（内置BBX24W）：适用1.5ml旋盖离心管（带密封圈），可同时处理24个样品，透明腔体方便观察样品处理情况，带透明外腔，可产生负压，避免因样品管意外泄漏造成气溶胶扩散，适合处理生物高致病危险样品，可随生物安全柜一起消毒；
使用Bullet Blender处理样品的部分参考文献
主动脉（小鼠）
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Lee YW, Lee WH, Kim PH (2010) Role of NADPH oxidase in interleukin-4-induced monocyte chemoattractant protein-1 expression in vascular endothelium. Inflamm Res 59:755-765
Lee YW, Lee WH, Kim PH (2010) Oxidative mechanisms of IL-4 induced IL-6 expression in vascular endothelium. Cytokine 49:73-79
主动脉和肝脏（小鼠）
Shai SY, Sukhanov S, Higashi Y, Vaughn C, Rosen C, Delafontaine, P (2010) Low circulating insulin-like growth factor I increases atherosclerosis in ApoE-deficient mice.Am J Physiol Heart Circ Physiol 300(5):H1898-906.
膀胱和肾脏（小鼠，分离细菌）
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大脑（仓鼠）
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大脑（人体）
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大脑（小鼠，分离细胞核）
Henry S, Bigler S, Wang J (2009) High throughput analysis of neural progenitor cell proliferation in adult rodent hippocampus. Biosci Trends 3:233-238
大脑（小鼠）
Ash ES, Alavijeh MS, Palmer AM, Mitchelmore C, Howlett DR, Francis PT, Broadstock M, Richardson JC (2011) Neurochemical changes in a double transgenic mouse model of Alzheimer's disease fed a pro-oxidant diet.Neurochem Int 57:504-11.
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线虫（B. xylophilus）
Kang JS, Koh YH, Moon YS, Lee SH (2011) Molecular properties of a venom allergen-like protein suggest a parasitic function in the pinewood nematode Bursaphelenchus xylophilus. International Journal for Parasitology 10.1016/j.ijpara.2011.10.006.
线虫（C. elegans）
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Billing O, Kao G, Naredi P (2011) Mitochondrial Function Is Required for Secretion of DAF-28/Insulin in Mitochondrial Function Is Required for Secretion of DAF-28/Insulin in C. elegans. PLoS One 6:e14507
毛虫（P. isabella）
Marshall KE, Sinclair BJ (2011) Threshold temperatures mediate the impact of reduced snow cover on overwintering freeze-tolerant caterpillars. Naturwissenschaften 10.1007/s00114-011-0866-0.
培养细胞 (人体)
Wu S, Wang L, Guo W, Liu X, Liu J, Wei X, Fang B. (2011) Analogues and derivatives of oncrasin-1, a novel inhibitor of the C-terminal domain of RNA polymerase II and their antitumor activities. J Med Chem 54:2668-79
结肠（人体）
Repnik K, Potocnik U. (2010) CTLA4 CT60 Single-Nucleotide Polymorphism Is Associated with Slovenian Inflammatory Bowel Disease Patients and Regulates Expression of CTLA4 Isoforms. DNA Cell Biol 29:603-10
结肠（小鼠）
Lowe EL, Crother TR, Rabizadeh S, Hu B, Wang H, Chen S, Shimada K, Wong MH, Michelsen KS, Arditi M (2010) Toll-Like Receptor 2 Signaling Protects Mice from Tumor Development in a Mouse Model of Colitis-Induced Cancer. PLoS One 5(9): e13027
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果蝇（Drosophila melanogaster）
Marshall KE, Sinclair BJ (2010) Repeated stress exposure results in a survival-reproduction trade-off in Drosophila melanogaster. Proc Biol Sci 277:963-969
Bazinet A, Marshall KE, MacMillan HA, Williams CM, Sinclair BJ (2010) Rapid changes in desiccation resistance in Drosophila melanogaster are facilitated by changes in cuticular permeability. J Insect Physiol 56:2006-12
心脏(心室-小鼠)
O'Shea KM, Chess DJ, Khairallah RJ, Rastogi S, Hecker PA, Sabbah HN, Walsh K, WC Stanley (2010) Effects of adiponectin deficiency on structural and metabolic remodeling in mice subjected to pressure overload. Am J Physiol Heart Circ Physiol 298: H1639-H1645
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心脏
Lemon DD, Horn TR, Cavasin MA, Jeong MY, Haubold KW, Long CS, Irwin DC, McCune SA, Chung E, Leinwand LA, McKinsey TA (2011) Cardiac HDAC6 catalytic activity is induced in response to chronic hypertension. J Mol Cell Cardiol 51:41-50
钩虫(幼虫)
Krepp J, Gelmedin V, Hawdon JM (2010) Characterisation of hookworm heat shock factor binding protein (HSB-1) during heat shock and larval activation. Int J Parasitol 10.1016/j.ijpara.2010.12.001
肠(十二指肠和盲肠，鸡)
Shaw AL, van Ginkel FW, Macklin KS, Blake JP (2011) Effects of phytase supplementation in broiler diets on a natural Eimeria challenge in naive and vaccinated birds. Poult Sci 90:781-790
肠粘膜（猪）
Lu J, Grenache D (2010) High-throughput tissue homogenization method and tissue-based quality control materials for a clinical assay of the intestinal disaccharidases. Clinica Chimica Acta 411:754-757
肝脏和脑（大鼠）
Zahr NM, Luong R, Sullivan EV, Pfefferbaum A (2010) Measurement of Serum, Liver, and Brain Cytokine Induction, Thiamine Levels, and Hepatopathology in Rats Exposed to a 4-Day Alcohol Binge Protocol. Alcohol Clin Exp Res 34:1858-70
肝脏（鱼）
Roberts SC, Noyes PD, Gallagher EP, Stapleton HM (2011) Species-Specific Differences and Structure-Activity Relationships in the Debromination of PBDE Congeners in Three Fish Species.Environ Sci Technol Feb 3. [Epub ahead of print]
肝脏（猴）
Rayner KJ, Esau CC, Hussain FN, McDaniel AL, Marshall SM, van Gils JM, Ray TD, Sheedy FJ, Goedeke L, Liu X, Khatsenko OG, Kaimal V, Lees CJ, Fernandez-Hernando C, Fisher EA, Temel RE, Moore KJ (2011) Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides .Nature478: 404-7
Lebold KM, Grant KA, Freeman WM, Wiren KM, Miller GW, Kiley C, Leonard SW, Traber MG (2010) Individual Differences in Hyperlipidemia and Vitamin E Status in Response to Chronic Alcohol Self-Administration in Cynomolgus Monkeys.Alcohol Clin Exp Res10.1111/j.1530-0277.2010.01364
肝脏（小鼠）
Chuang HL, Huang YT, Chiu CC, Liao CD, Hsu FL, Huang CC, Hou CC (2011) Metabolomics characterization of energy metabolism reveals glycogen accumulation in gut-microbiota-lacking mice. J Nutr Biochem 10.1016/j.jnutbio.2011.03.019
Hwang JT, Kim SH, Hur HJ, Kim HJ, Park JH, Sung MJ, Yang HJ, Ryu SY, Kim YS, Cha MR, Kim MS, Kwon DY (2011) Decursin, an Active Compound Isolated from Angelica gigas, Inhibits Fat Accumulation, Reduces Adipocytokine Secretion and Improves Glucose Tolerance in Mice Fed a High-Fat Diet. Phytother Res doi: 10.1002/ptr.3612
Rayner KJ, Sheedy FJ, Esau CC, Hussain FN, Temel RE, Parathath S, van Gils JM, Rayner AJ, Chang AN, Suarez Y, Fernandez-Herando C, Fisher EA, Moore KJ (2011) Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis. J Clin Invest 212:2921-2931.
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Huang L (2011) Nitric Oxide Formation From Inorganic Nitrate and Nitrite; Contribution from eukaryotic and prokaryotic pathways. Unpublished doctoral dissertation, Karolinska Institutet, Stockholm, Sweden
肺（小鼠）
Alder JK, Guo N, Kembou F, Parry EM, Anderson CJ, Gorgy AI, Walsh MF, Sussan T, Biswal S, Mitzner W, Tuder RM, Armanios M (2011) Telomere Length is a Determinant of Emphysema Susceptibility. Am J Respir Crit Care Med 184: 904-912
Ma W, Han W, Greer PA, Tuder RM, Toque HA, Wang KKW, Caldwell RW, Su Y (2011) Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease. J Clin Invest 4548-4566
肺（大鼠）
Konsavage WM, Zhang L, Wu Y, Shenberger JS (2011) Hyperoxia-induced Activation of the Integrated Stress Response in the Newborn Rat Lung. Am J Physiol Lung Cell Mol Physiol 10.?1152/?ajplung.?00174.?2011
微孢子虫（Microsporidia Nosema）
Bourgeois AL, Rinderer TE (2010) Genetic detection and quantification of Nosema apis and N. ceranae in the honey bee. J Inv, , ertebr Pathol 103:53-58
苔藓, , (Physcomitrella patens)
Augustine R, Pattavina KA, Tüzel E, Vidali L, Bezanilla M (2011) Actin Interacting Protein1 and Actin Depolymerizing Factor Drive Rapid Actin Dynamics in Physcomitrella patens. Plant Cell [Epub ahead of print]
肌肉（鱼）
Foott JS, Fogerty R (2011) Juvenile Stanislaus River Chinook salmon pathogen and physiology assessment: January – May 2011. . U.S. Fish and Wildlife Service FY2011 Technical Report.<
肌肉（人体）
Smith LR, Lee KS, Ward SR, Chambers HG, Lieber RL (2011) Hamstring contractures in children with spastic cerebral palsy result from a stiffer extracellular matrix and increased in vivo sarcomere length. J Physiol. 589(Pt 10):2625-39.
肌肉（小鼠）
Yamada E, Pessin JE, Kurland IJ, Schwartz GJ, Bastie CC (2010) Fyn-dependent regulation of energy expenditure and body weight is mediated by tyrosine phosphorylation of LKB1. Cell Metab 11:113-124
Welle S, Mehta S, Burgess K (2011) Effect of postdevelopmental myostatin depletion on myofibrillar protein metabolism. Am J Physiol Endocrinol Metab 300:E993-E1001
肌肉（大鼠）
Chiang J, Shen YC, Wang YH, Hou YC, Chen CC, Liao JF, Yu MC, Juan CW, Liou KT (2009) Honokiol protects rats against eccentric exercise-induced skeletal muscle damage by inhibiting NF-kappaB induced oxidative stress and inflammation. Eur J Pharmacol 610:119-127
鼻息肉（人体）
Poposki JA, Uzzaman A, Nagarkar DR, Chustz RT, Peters AT, Suh LA, Carter R, Norton J, Harris KE, Grammer LC, Tan BK, Chandra RK, Conley DB, Kern RC, Schleimer RP, Kato A (2011) Increased expression of the chemokine CCL23 in eosinophilic chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol 128:73-81
Tan BK, Li QZ, Suh L, Kato A, Conley DB, Chandra RK, Zhou J, Norton J, Carter R, Hinchcliff M, Harris K, Peters A, Grammer LC, Kern RC, Mohan C, Schleimer RP (2011) Evidence for intranasal antinuclear autoantibodies in patients with chronic rhinosinusitis with nasal polyps.. J Allergy Clin Immunol 128:1198-1206
鼻粘膜（小鼠）
Xie F, Zhou X, Behr M, Fang C, Horii Y, Gu J, Kannan K and Ding X (2010) Mechanisms of olfactory toxicity of the herbicide 2,6-dichlorobenzonitrile: Essential roles of CYP2A5 and target-tissue metabolic activation. Toxicol Appl Pharmacol 249:101-6
Xie F, Zhou X, Genter MB, Behr M, Gu J, Ding X (2011) The Tissue-Specific Toxicity of Methimazole in the Mouse Olfactory Mucosa Is Partly Mediated through Target-Tissue Metabolic Activation by CYP2A5. Drug Metab Dispos. 39(6):947-51.
咽（人体）
Winder DM, Ball SL, Vaughan K, Hanna N, Woo YL, Fränzer JT, Sterling JC, Stanley MA, Sudhoff H, Goon PK (2009) Sensitive HPV detection in oropharyngeal cancers. BMC Cancer 9:440
土豆
Rommens C M, Shakya R, Heap M, Fessenden K (2010) Tastier and Healthier Alternatives to French Fries. J Food Sci 75: H109H115
小肠和回肠(豚鼠)
Kang M, Maguma HT, Smith TH, Ross GR, Dewey WL, Akbarali HI (2011) The role of ?-arrestin2 in the mechanism of morphine tolerance in the mouse and guinea pig gastrointestinal tract. J Pharmacol Exp Ther 10.1124/jpet.111.186320
皮肤（人体）
Marji J, O'Donoghue SI, McClintock D, Satagopam VP, Schneider R, Ratner D, Worman HJ, Gordon LB, Djabali K (2010) Defective Lamin A-Rb Signaling in Hutchinson-Gilford Progeria Syndrome and Reversal by Farnesyltransferase Inhibition. PLoS One 5(6): e11132
皮肤（大鼠）
von Grote EC, Venkatakrishnan V, Duo J, Stenken JA (2011) Long-term subcutaneous microdialysis sampling and qRT-PCR of MCP-1, IL-6 and IL-10 in freely-moving rats. Mol Biosyst. 7(1):150-61
胃（小鼠，分离幽门螺旋杆菌）
Rolig AS, Carter JE, Ottemann KM (2011) Bacterial chemotaxis modulates host cell apoptosis to establish a T-helper cell, type 17 (Th17)-dominant immune response in Helicobacter pylori infection. PNAS 108; 19749-19754.
肿瘤（小鼠）
Schewe DM, Aguirre-Ghiso JA (2008) ATF6alpha-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo. Proc Natl Acad Sci 105:10519-10524
黑色素瘤（人体）
Poulikakos PI, Persaud Y, Janakiraman M, Kong X, Ng C, Moriceau G, Shi H, Atefi M, Titz B, Gabay MT, Salton M, Dahlman KB, Tadi M, Wargo JA, Flaherty KT, Kelley MC, Misteli T, Chapman1 PB, Sosman JA, Graeber TG, Ribas A, Lo RS, Rosen N, Solit DB (2011) RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E). Nature 1doi: 10.1038/nature10662. [Epub ahead of print]
胸部（蜜蜂）
Bourgeois AL, Rinderer TE (2009) Genetic characterization of Russian honey bee stock selected for improved resistance to Varroa destructor. J Econ Entomol 102:1233-1238
Bourgeois L, Sheppard WS, Sylvester HA, Rinderer TE (2010) Genetic Stock Identification of Russian Honey Bees J Economic Entomology 103:917-924
脐带和胎便（人体）
Marin SJ, Christensen RD, Baer VL, Clark CJ, McMillin GA (2011) Nicotine and metabolites in paired umbilical cord tissue and meconium specimens. Ther Drug Monit 33(1):80-5.
阴道（兔）
Alt C, Harrison T, Dousman L, Fujita N, Shew K, Tran TT, Shayesteh S, Matsukawa A, Mirsalis J, D'Andrea A (2009) Increased CCL2 expression and macrophage/monocyte migration during microbicide-induced vaginal irritation. Curr HIV Res 7:639-649
酵母菌（C. albicans）
Finkel JS, Yudanin N, Nett JE, Andes DR, Mitchell AP. (2011) Application of the systematic "DAmP" approach to create a partially defective C. albicans mutant. Fungal Genet Biol 48:1056-61.
Ganguly S, Bishop AC, Xu W, Ghosh S, Nickerson KW, Lanni F, Patton-Vogt J, Mitchell AP (2011) Zap1 control of cell-cell signaling in Candida albicans biofilms. Eukaryotic Cell doi:10.1128/EC.05196-11
Rauceo JM, Blankenship JR, Fanning S, Hamaker JJ, Deneault JS, Smith FJ, Nantel A, Mitchell AP (2008) Regulation of the Candida albicans cell wall damage response by transcription factor Sko1 and PAS kinase Psk1. Mol Biol Cell 19:2741-2751
酵母菌（S. cerevisiae）
Wu X, Liu L, Huang M (2011) Analysis of changes in protein level and subcellular localization during cell cycle progression using the budding yeast Saccharomyces cerevisiae. Methods Mol Biol 782:47-57
Vorvis C, Markus SM, Lee WL (2008) Photoactivatable GFP tagging cassettes for protein-tracking studies in the budding yeast Saccharomyces cerevisiae. Yeast 25:651-659
酵母菌（S. passalidarum)
Hou X, Yao S (2011) Improved inhibitor tolerance in xylose-fermenting yeast Spathaspora passalidarum by mutagenesis and protoplast fusion. Appl Microbiol Biotechnol 2011 Nov 25. [Epub ahead of print]
酵母菌 (S. passalidarum, P. Stipitis)
Hou X (2011) Anaerobic xylose fermentation by Spathaspora passalidarum. Appl Microbiol Biotechnol 2011 Nov 30. [Epub ahead of print]
酵母菌
Blankenship JR, Fanning S, Hamaker JJ, Mitchell AP (2010) An extensive circuitry for cell wall regulation in Candida albicans. PLoS Pathog 6:e10000752
Meriin AB, Wang Y, Sherman MY (2010) Isolation of aggresomes and other large aggregates. Curr Protoc Cell Biol Chapter 3:Unit 3.38.1-9.
各种组织（小鼠肝脏、心脏、肌肉，分离提取病毒）
Miller BF, Robinson MM, Bruss MD, Hellerstein M, Hamilton KL (2011) A comprehensive assessment of mitochondrial protein synthesis and cellular proliferation with age and caloric restriction. Aging Cell 10.1111/j.1474-9726.2011.00769
各种组织（小鼠脊椎、大脑、胃、小肠、结肠，分离提取病毒）
Lancaster KZ, Pfeiffer JK (2010) Limited trafficking of a neurotropic virus through inefficient retrograde axonal transport and the type I interferon response. PLoS Pathog 6:e10000791
各种组织（小鼠肝脏、肌肉、脂肪、主动脉）
Carlstrom M, Larsen FJ, Nystrom T, Hezel M, Borniquel S, Weitzberg E, Lundberg JO (2010) Dietary inorganic nitrate reverses features of metabolic syndrome in endothelial nitric oxide synthase-deficient mice. PNAS 10.1073/pnas.1008872107
各种组织（小鼠肝脏、脾脏、肺、肾脏、脑、心脏、主动脉、腹膜巨噬细胞）
Rayner KJ, Surrez Y, Drvalos A, Parathath S, Fitzgerald ML, Tamehiro N, Fisher EA, Moore KJ, Fernrndez-Hernandomi C (2010) MiR-33 coordinates genes regulating cholesterol homeostasismiR-33 coordinates genes regulating cholesterol homeostasis. Science 328:1570-1573
各种组织（小鼠主动脉、肝脏、肾脏）
Fox KA, Longo M, Tamayo E, Kechichian T, Bytautiene E, Hankins GDV, Saade GR, Costantine MM (2011) Effects Of Pravastatin On Mediators Of Vascular Function In A Mouse Model Of Soluble Fms-Like Tyrosine Kinase-1Induced Preeclampsia. Am J Obstet Gynecol doi:10.1016/j.ajog.2011.06.083
各种组织（小鼠膀胱、肝脏、肾脏、心脏、肠、肺、肌肉、直肠、皮肤、脾脏）
Choi HS, Nasr K, Alyabyev S, Feith D, Lee JH, Kim SH, Ashitate Y, Hyun H, Patonay G, Strekowski L, Henary M, Frangioni JV (2011) Synthesis and in vivo fate of zwitterionic near-infrared fluorophores. Angew Chem Int Engl 50:6258-63
各种组织（小鼠耳、肝脏、脾脏）
Choi KY, Chang K, Pickel JM, Badger JD 2nd, Roche KW (2011) Expression of the metabotropic glutamate receptor 5 (mGluR5) induces melanoma in transgenic mice. Proc Natl Acad Sci U S A 108: 15219-24
各种组织（小鼠肝脏、脾脏）
Smith JS, Xu Z, Tian J, Palmer D, Ng P, Byrnes AP (2011) The Role of Endosomal Escape and Mitogen-Activated Protein Kinases in Adenoviral Activation of the Innate Immune Response. PLoS one 6(10): e26755.
各种组织（小鼠肌肉、脑，分离提取病毒）
Lancaster KZ, Pfeiffer JK (2011) Mechanisms Controlling Virulence Thresholds of Mixed Viral Populations. J Virol 85:9778-88
斑马鱼（坯胎）
Chen CF, Chu CY, Chen TH, Lee SJ, Shen CN, Hsiao CD (2011) Establishment of a Transgenic Zebrafish Line for Superficial Skin Ablation and Functional Validation of Apoptosis Modulators In Vivo. PLos One 6: e20654
Saili KS, Corvi MM, Weber DN, Patel AU, Das SR, Przybyla J, Anderson KA, Tanguay RL. (2011) Neurodevelopmental low-dose bisphenol A exposure leads to early life-stage hyperactivity and learning deficits in adult zebrafish. Toxicology 10.1016/j.ijpara.2011.10.006
浮游动物（Daphnia Magna）
Chen CF, Chu CY, Chen TH, Lee SJ, Shen CN, Hsiao CD (2011) Predation by zooplankton on Batrachochytrium dendrobatidis: Biological control of the deadly amphibian chytrid fungus. Biodiversity and Conservation DOI: 10.1007/s10531-011-0147-4
用户对Bullet Blender快速组织细胞破碎仪的评价：
"It's a very useful device for making tissue lysates. We no longer use sonication for DNA, RNA and protein preparation from multiple tissue samples."
Prof. Michael Sherman, Boston University School of Medicine
"The Bullet Blender has made our clinical lab much more efficient; we get consistent results in less time. We cannot imagine going back to hand vortexing for our whole blood extractions."
Kimberly Dumont, supervisor, Dartmouth Reference Lab
"I can count on it for fast consistent results."
Dr. Denis Schewe, Mt. Sinai Medical Center, New York City
"What I've found is that the instrument works very well, is faster than the Bead Beater, accommodates more samples and is considerably quieter. . . . I get consistently uniform cell breakage."
Dr. Joseph Geisberg, Harvard Medical School
"This past January [2008] we purchased a Bullet Blender from Next Advance. ... Let me begin by saying that we are extremely satisfied with the product! We have been able to implement it into a number of protocols that we use in our lab. Other labs in our department have also taken a liking to the unit and have been using it along side our lab."
Dr. Kyle Bender, Queen's University, Kingston, Ontario, Canada
"The Bullet Blender lets us reduce variability and user error and increase productivity."
Dr. Scott Gridley, Director of Protein Sciences, Blue Sky Biotech, Inc., Worcester, Massachusetts
"The Bullet Blender homogenizes our samples so well, our protein yield is almost too good."
Dr. Donna Newman, North Carolina State University
"Using the Dounce homogenizer, I can process eight tumors in an hour and a half. With the Bullet Blender, I can homogenize twenty in fifteen minutes."
Dr. Alejandro Adam, Albany Medical Center, New York
"I love it!! ... I'm going to try and get another one."
Shari Kohut, MLT ASCP, Women and Children's Hospital of Buffalo
"We used to use a mortar and pestle grinder and it took hours and hours and hours to homogenize our samples. The Bullet Blender has increased our throughput tremendously."
Dr. Christopher Ward, University of Maryland
"That machine is a lifesaver! ... It worked out so well, we're contemplating purchasing a second one."
Dr. Lou Casta, Fraunhofer USA
"Our extraction staff have loved the Bullet Blenders, they have really helped with the workflow!" ... "They do a great job homogenizing for us, and save our techs from repetititve motion injuries, and help with time management. We love them!"
Chantry Clark, CDAT Lead Technologist, ARUP Labs, Utah
"It does work great for westerns ... It's a lot faster."
Dr. Timothy Bartness, Georgia State University
"...the results are great! ... We have run it on the Agilent chip and the RNA integrity numbers (RIN) are 10 and 8.6 for both of the samples."
Phuong Nguyen, Translational Genomics Group, Baylor Health
"We use the Bullet Blender to disrupt mycobacteria and different types of gram-negative bacteria for a variety of applications and are very happy with the results we get."
Martin Pavelka, Ph.D., University of Rochester, School of Medicine and Dentistry
"I love the Bullet Blender! We work on the mouse model for chlaymdia and often have to remove the uteri from the mice and homogenize by hand. I used it the other day and was amazed how well it homogenized the tissue. We can do 24 samples in just 5 minutes-amazing. What used to take us hours we can do in just 5 minutes."
Cheryl Champion, Ph.D., Pathology & Laboratory Medicine, UCLA
